A new study has shed light on how weight-loss and diabetes injections such as Wegovy and Ozempic may have wider medical benefits than we first thought. The researchers found that these drugs on the brain to lessen body-wide inflammation, which could explain why they seem to reduce heart attacks more than expected from their weight-loss effects alone. The drugs belong to a class of medications that mimic a gut hormone called GLP-1, which normally lowers appetite, makes people feel full and the release of insulin, a hormone involved in blood sugar regulation. Several studies have suggested that, as well as causing people to lose weight, GLP-1 mimics also lower inflammation. To investigate the behind this anti-inflammatory effect, the researchers conducted experiments in mice. They found that GLP-1 mimics reduced the animals’ inflammatory response to a bacterial infection, but only when the mice had the receptor for GLP-1 on their brain cells. This means that the drugs reduce inflammation by influencing the brain, and not just by weight loss.