Anna was a 15-year-old girl who loved to out with her friends, play soccer, and listen to music. She was looking forward high school and exploring new subjects and activities. But then the covid-19 pandemic , and everything changed. She had to stay at home, attend online classes, and avoid social gatherings. She felt lonely, bored, and anxious. She was not alone. Many adolescents around the world experienced similar challenges during the pandemic. A new study found that the pandemic had a particularly large effect on the ageing rate of adolescent girls’ brains. The researchers speculated that the pandemic might have the normal development of the adolescent brain, which is sensitive to environmental influences. They suggested that factors such as stress, isolation, lack of stimulation, and reduced physical activity might have contributed to the brain changes. They also warned that these changes might have long-term for cognitive and mental health. They called for more research and interventions to support adolescents during and after the pandemic.